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Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above
JAK-2/STAT-3 ,
This finding suggests that novel biomarkers associated with disulfidptosis could serve as valuable tools in the clinical diagnosis, prognostic prediction, and therapeutic targeting of HCC
Tanabe et al., 2019)
Chao CL, Tsai HH, Lee CM, Hsu SM, Kao JT, Chien KL, Sung FC, and Lee YT (1999b)
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