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The discontinuation rate (19.8%) was higher than reported for the PIONEER trials (713% with oral semaglutide 14 mg) [12, 14,15,16,17, 29, 38] and for the SURE Netherlands study for subcutaneous semaglutide (approximately 5%) [30]
The shelf life is 3 years
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Animal studies and limited human observations indicate that the drug crosses into milk at approximately 3-4% of the maternal dose, meaning an infant would receive roughly 3-40 micrograms daily if the mother were on a standard 1-2 mg weekly dose
Reputable providers should be willing to discuss the limitations of the available data, explain why a treatment is being recommended, and outline alternative options
Before study initiation, the proportion of patients using a GLP-1 RA was lower than 40% in both cohorts
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