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Male study subject, 46 years old, diagnosed with AGA, Norwood V
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
These findings raise important questions about the molecular mechanisms underlying sertralines effects on fungal membranes and whether they parallel its known actions in human cells
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Rather, evidence for these alterations has been collected piecemeal, limiting the potential to inform our understanding of the interactions amongst relevant biochemical pathways
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