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Furthermore, Gs utilization in GLP-1R signaling was enhanced by X-box binding protein 1 (XBP1) and activating transcription factor 6 (ATF6)two key transcription factors involved in endoplasmic reticulum (ER) stress responses, have been shown to selectively enhance Gs signaling through GLP-1R, whereas Gq signaling remains unaffected (Sawada et al., 2020

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Beyond 6 Months: Long-term studies demonstrate that these medications continue to provide sustained benefits with ongoing treatment

however, no clinical data based on alcohol intake are available