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CANVAS demonstrated a 14% reduction in MACE in patients with T2DM and a high cardiovascular risk ( 4.1.2 Cardiovascular results in studies aimed at CVD The CREDENCE clinical trial evaluated the effects of canagliflozin (100 mg daily) versus placebo in 4,401 patients with T2DM and CKD

This reflects the body composition shift rather than weight loss in the conventional sense

Moreover, mounting evidence suggests that vitamin D may be a critical missing link in virtually all autoimmune diseases, including lupus

Growth hormone release, which peaks in the first few hours of sleep, directly stimulates fibroblast activity

It means we do not have the quality of evidence needed to make confident claims about efficacy