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Wang X, Qi M, Yang L, Yang L, Wang X, Zhang F, et al
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Human Studies In humans a combination of 2 mg of melatonin plus 60 mg of vitamin C for females or 75 mg of vitamin C for males resulted in significant improvement in postoperative outcomes of periodontal disease at 6 months compared to 3 months and the non-treated group (2)
These medications are administered via subcutaneous injection , with dosing frequencies ranging from once daily to once weekly depending on the specific agent