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The bottom line There are lots of positive health benefits from using a GLP-1 to eat less and lose weight, but there are also a few challenges, especially losing bone density and muscle mass

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While earlier studies suggested a possible modest increase in risk, more recent comprehensive analyses have found no significant association after adjusting for confounding factors such as obesity, diabetes duration, and concurrent medications

nausea decreases with ongoing usage a steady weight loss occurs in some patients over 2 years (may be related to nausea & CNS-mediated loss of appetite) there is an increased risk of hypoglycemia when exenatide is used with a sulfonylurea The dose of the sulfonylurea may need to be reduced if hypoglycemia occurs when combined with exenatide Most serious : rare & sometimes fatal necrotizing or hemorrhagic pancreatitis When initiating patients on Byetta, watch for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back, which may or may not be accompanied by vomiting)

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