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However, while the initial evidence from animal studies looks extremely promising, the jury is still out as far as humans are concerned

PMID: 39980735

Adjust doses of concurrent medications (especially sulphonylureas or insulin) as directed to prevent hypoglycaemia

Again, the peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family, comprising PGC-1, PGC-1, and PGC-1-related coactivator (PRC), plays a pivotal role in regulating mitochondrial biogenesis, oxidative metabolism and energy homeostasis across various tissues, including skeletal muscle [58]

Large body-composition outcome trials are lacking