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Glucagon-like peptide-1 (GLP-1)-based therapies improve all these variables but whether the dual GLP-1 / glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide is superior to semaglutide in attaining therapeutic targets remains unclear

Four to five small meals instead of three large ones reduces the burden on a slower stomach

Incretins (GLP-1 and GLP-1-2) are released from proximal intestinal enteroendocrine L cells and flow directly into the portal blood compartment, the stimulus for their release is assumed to be the glucose concentration within this superior mesenteric capillary compartment, determined by GLUT2 K m (Table 1E equation 2)

Most users notice appetite changes first, then gradual weight changes over weeks to months, especially when dose increases are done slowly and side effects are managed

Wang J-L, Yang Q, Hajnal A, Rogers AM