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Increased expression of GPX3 has been associated with unfavorable patient prognosis in OC, stem cells and certain colorectal cancers (44,52)

However, not everyone is sold on the efficacy or necessity of glutathione supplementation

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However, using variants that do not dimerize, it has been recently described that homodimer formation of GCL is not required for enzyme activation (Yang et al., 2019)

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