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An OA mouse model was successfully established by injecting monosodium iodoacetate (MIA) in mouse knee joints 25 , specifically, involving anesthetic administration with 1.25% tribromoethanol (Bimake, M2920) at a dose of 0.2 mL/10 g body weight, followed by intra-articular injection of 10 L MIA (50 mg/ml, Sigma-Aldrich, 57858-25G-F) into the right knee joint using a 30-gauge needle

Repaglinide works by stimulating the release of insulin from the beta islet cells of the pancreas, hence lowering the blood glucose

Utah patients receive personalized treatment options that keep the program aligned with their needs

Policy Note: This article is a slightly abridged version of a review first published in the Cleveland Clinic Journal of Medicine (2025;92(3):147-151)