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Activation of frataxin can enhance PINK1/Parkin-mediated mitophagy, which can significantly ameliorate lipid accumulation induced by a high-fat diet and free fatty acids [258, 259]

If thats the case, clinicians recommend not stopping abruptly

Thus, we found that a distinct subset of proteins are targets for persulfide accumulation in wild-type, GR-null, or TR/GR-null liver samples, suggesting that the persulfide-reducing capacities of the Trx and GSH systems might be protein persulfidespecific and potentially involved in different signaling pathways

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