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According to him, tracking, monitoring, and optimizing this risk reduction is critical to reducing the complications of cardiovascular-kidney-metabolic disease. However, as with other GLP-1 receptor agonists, orforglipron carries safety considerations

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Drugs Exp Clin Res 1992;18(4):147-153

Further increases in BMI can adversely affect the long term health of these patients, because many of them are overweight prior to surgery