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Cellular -synuclein pathology is associated with bioenergetic dysfunction in Parkinsons iPSC-derived dopamine neurons

Some worry these drugs bypass deeper issues

doi: 10.1196/annals.1320.019 40 PennistonKLTanumihardjoSA

The comparator arm was placebo, a GLP-1 RA (subcutaneous administration of semaglutide 1 mg once-weekly) and basal insulin in three [18, 19, 22], one [24, 25] and two trials [20, 21], respectively, while one trial included both a placebo arm and a GLP-1 RA arm (dulaglutide 1.5 mg once-weekly) [23]