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Exosomes also play a key role in tissue repair

As Yaribeygi, Journal of Cellular Physiology emphasized, while mitochondrial peptides hold therapeutic promise, their systemic effects require caution due to the lack of long-term human studies

TransCon PTH Hypoparathyroidism (adolescents) Phase 3 Multinational TransCon CNP Achondroplasia (infants) Pivotal Phase 2 Multinational TransCon CNP Achondroplasia (adolescents) Pivotal Phase 2b Multinational TransCon CNP Hypochondroplasia (children aged 2-18) Phase 3 Multinational TransCon CNP + TransCon hGH Achondroplasia (children aged 2-11) Phase 2 Multinational TransCon CNP + TransCon hGH Achondroplasia (children aged 2-18) Phase 3 Multinational TransCon CNP + TransCon hGH Hypochondroplasia (children aged 2-18) Phase 3 Multinational Partner Programs TransCon hGH Pediatric GHD BLA submitted China TransCon hGH Pediatric GHD Phase 3 Japan TransCon PTH Hypoparathyroidism (adults) Completed Phase 3 China TransCon CNP Achondroplasia Completed Phase 2 China TransCon CNP Achondroplasia Phase 3 Japan Oncology Indication Status Region Lead Indication TransCon IL-2 / Various tumor types Phase 2 Multinational Note: The above chart lists our current clinical interventional trials related to the disclosed indications

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AMG 133 functionally inhibits GIP signalling through human and cynomolgus monkey GIPR with similar potency (half maximal inhibitory concentration (IC 50 ) of 42.4 nM and 26.5 nM, respectively), whereas it has more than 20-fold lower potency for inhibition of GIP signalling through rat GIPR (IC 50 = 822 nM) and did not fully antagonize mouse GIPR with concentrations of up to 3 M