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We observed no significant changes in the expression of p53 or p21 in keloid lesions or fibroblasts compared to those in normal skin

Lown M, Fuller R, Lightowler H, Fraser A, Gallagher A, Stuart B, Byrne C, Lewith G

Sleep problems in Rett syndrome often include: insomnia: Difficulty falling asleep or staying asleep at night, which is one of the most common complaints for caregivers excessive daytime sleepiness: Feeling a constant need to nap or struggling to stay awake during daylight hours sleep-disordered breathing: Experiencing abnormal breathing patterns that can disrupt the restorative stages of sleep nighttime vocalizations: Laughing, screaming, or talking while asleep, often occurring without the person waking up bruxism: Clenching or grinding the teeth during the night seizures: Experiencing abnormal electrical brain activity while sleeping, which can be difficult to detect The bodys natural circadian rhythms are often disrupted in those with Rett syndrome