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In 2021, the Amgen team published the preclinical research progress of their dual-function molecule project AMG 133, which involves GIPR antibodies and GLP-1R, for the first time in "Cell Reports Medicine"
retatrutide adds GCGR to both
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For research handling, the powder is typically reconstituted with bacteriostatic water
The acylated side chain and amino acid substitutions extend half-life in vivo and also improve storage stability
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