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92 Resveratrol also inhibits circulating oncogenic microRNAs (miRs) such as miR-19, miR-21, and miR-30a-5p, thereby suppressing the expression of genes that code for epidermal growth factor receptor, signal transducer and activator of transcription, COX-2, and downregulating the mTOR signaling pathway

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Normalisation of the lipid spectrum, suppression of the growth of atherosclerotic plaques and their stabilisation, as well as endothelial dysfunction improvement can reduce the risk of both HFpEF onset and progression

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The potency of oral medications diminishes as they travel through the digestive tract, and absorption is further slowed by the transit time through the stomach and intestines prior to entering the bloodstream