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Real-world persistence is low: about half discontinue within a year and roughly three-quarters within two years , often due to cost or side effectsraising the risk of rebound weight and lost health gains (Scientific American on discontinuation rates)

Zanelli SA et al

Distillation removes minerals and contaminants, but it doesn't sterilize

PlexusDx Precision Peptide Genetic Test ($298) identifies variants in other appetite-control genes that influence how strongly semaglutide suppresses cravings for sweets

Some also prefer it to maximize appetite suppression during the week when routines might be more challenging