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On the other hand, MSG significantly declined in the GPX, catalase and SOD activity in comparison with the controls, while L-carnitine significantly dealt with this effect and improved the anti-oxidant enzyme activity (Table 2)

Environmental electrophile-mediated toxicity in mice lacking Nrf2, CSE, or both

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Iranshahi et al., 2011

In Long COVID, oxidative stress may be driven by: persistent immune activation mitochondrial dysfunction mast cell activation (MCAS) chronic inflammation autonomic nervous system dysregulation psychological stress (PTSD, illness trauma) Even everyday factors can worsen the burden: travel overexertion poor sleep emotional stress Supporting the Body Against Oxidative Stress While research is ongoing, strategies that may help reduce oxidative stress include: Foundational Support Anti-inflammatory nutrition Adequate hydration Sleep optimization Stress reduction Nervous System Regulation Breathwork Pacing strategies Reducing overstimulation Nutritional & Clinical Considerations Antioxidant support (as clinically appropriate) Mitochondrial support Addressing histamine and MCAS if present Always consult with a qualified provider before starting new treatments or supplements