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Curr Opin Neurol 20:453464

Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis

When exposed to a hyperglycemic milieu, the GIPR was found to downregulate in a study of pancreatic islet cells (59) and the patients with T2DM might express a small amount of GIPR or defective GIPR (60, 61)

the maintenance of patients liver and kidney function is obviously important for the bodys ability to react to infections, including COVID-19

In plain terms, even if your body has developed some degree of resistance to GLP-1 signaling, the GIP pathway and the biased signaling properties of tirzepatide can still drive insulin response