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It has been shown in clinical studies to produce significant weight loss results, with many patients losing a notable percentage of their body weight when used as part of a comprehensive weight loss plan

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Science 189 , 347358 (1975)

It also modulates NF-kB, one of the primary inflammatory signaling pathways involved in chronic low-grade inflammation

This study shows that glutamate can be converted to -ketoglutarate in cancer cells by either GLUD or aminotransferases, and that the relative contribution of each pathway varies by cell type