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The hormonal drivers of appetite and weight gain that these medications address do not resolve simply because weight has been lost
References Bendotti, G., Montefusco, L., Lunati, M
First-generation GLP-1 drugs, like Ozempic, mimic GLP-1, an incretin hormone in the gut that regulates blood sugar, slows digestion, and signals fullness to the brain
Importantly, while RCTs consistently demonstrate robust short-term glycemic improvements, real-world data suggest that long-term treatment continuity remains a major challenge
References: National Center for Biotechnology Information
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