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New or worsening heartburn that does not respond to over-the-counter antacids, as this may indicate gastroesophageal reflux disease requiring treatment
Some children show quick changes, while others may need several weeks or months
In controlled studies on aged skin, GHK-Cu tightened skin, improved elasticity and firmness, and reduced fine lines, wrinkles and photodamage

Multifunctionality and possible medical application of BPC-157: literature and patent review (2025) Current Pharmaceutical Design (PMC) Sikiric P et al
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