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*Correspondence: Sheila Donnelly, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

For absorption-related deficiency such as pernicious anaemia, intramuscular hydroxocobalamin 1 mg on alternate days for two weeks is used as a loading dose, followed by maintenance injections every two to three months

Patients in their late 30s to early 50s who have begun noticing collagen loss but have not yet developed deep structural atrophy represent the sweet spot

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