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In SURMOUNT-1 , once-weekly tirzepatide in adults with obesity produced substantial, dose-dependent mean weight reductions over roughly 72 weeks versus placebo

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The review excluded articles that were not available in the English language, lacked full-text access, or were limited to case reports, expert opinion, or conference abstracts

It should not be surprising that most of the side effects are related to the mechanism of actions and can be somewhat predicted by the anatomical location of the GLP-1 receptors