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17 However, insulin therapy has limitations, such as the burden of injections and suboptimal patient acceptance, leading to suboptimal adherence in some patients
Because Retatrutide remains investigational, researchers continue collecting long-term safety information
SURPASS-2: The Only Head-to-Head Trial The SURPASS-2 trial (NEJM, 2021) is the most important study in this comparison because it directly tested tirzepatide against semaglutide in 1,879 patients with type 2 diabetes over 40 weeks
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Indicators of high risk include being 55 years of age or older with coronary, carotid, or lower extremity artery stenosis of more than 50% or with left ventricular hypertrophy
