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PubMed, Lu, Jingtong, et al
Attenuation of adipocyte triacylglycerol hydrolase activity decreases basal fatty acid efflux
To create a hypothetically effective synthetic peptide Melanotan 2, they subjected the naturally occurring 13-amino acid peptide, -MSH, to a sequence of chemical and amino acid changes
The test examines genetic variants like GIPR rs1800437 that affect peptide sensitivity and medication response
See the below from a Genetic Engineering and Biotechnology News story from 2013: The statement came less than two years after Tranzyme went public, and less than two months after the company pulled the plug on a Phase IIb study on the effects of three-times-daily dosing of its lead drug candidate, TZP-102 in patients with diabetes who have gastroparesis
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