Cell 172 , 409422.e21 (2018)
This section summarizes potential approaches to increasing the GSH system in the heart
While it is perhaps somewhat surprising that no group differences in metabolite concentrations were found, either for GABA (as has been shown before) or for GSH, we note that autism is an extremely heterogeneous condition, and that group differences, if present, may be small and relatively uninformative in understanding the broader autism phenotype(Loth et al., 2021)
During oxidative stress there is decrease in levels of GSH and increase in levels of GSSG and thus GSH/GSSG ratio decreases
After sonication, the lysate was centrifuged (17,000 rpm, 40 min) and the supernatant was purified using a nickel-nitrilotriacetic acid column (HisTrap HP