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JAMA: the journal of the American Medical Association 302, 412 (2009)
Animal care and handling Forty healthy adult female Sprague-Dawley albino rats (180220 g, 2 months old)
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It stimulates pathways associated with libido and reproductive behavior in both male and female models, leading to its recognition as a subject of interest in sexual function research
Importantly, the VECAD IGF- 1R KD model recapitulates key features of early microvascular aging prior to the onset of overt muscle atrophy, making it a useful experimental system for studying pre-sarcopenia and identifying early vascular biomarkers of functional decline
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