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Key Points Semaglutide is not FDA-approved to treat PCOS Some studies, however, show that semaglutide helped women with PCOS lose weight Weight loss often helps PCOS symptoms by reducing insulin resistance and hormonal imbalances Proper nutrition plays a key role in managing PCOS PCOS carries serious long-term health consequences, including an increased risk of diabetes, heart disease, and fertility challenges

The medication addresses the downstream insulin resistance and leptin insensitivity that persist even after cortisol normalization