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Archives of Physiology and Biochemistry, 130 (6), 678685

When NNMT activity is elevated as documented in obese adipose tissue, several cancer types, and aged skeletal muscle intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced

Liu, L., et al

4 Cardiovascular Risk Reduction In addition to managing blood glucose levels and promoting weight loss, GLP-1 receptor agonists have been found to reduce the risk of cardiovascular events, which is a critical consideration in diabetic patients