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GLYX-13 produces rapid antidepressant responses with key synaptic and behavioral effects distinct from ketamine
Other side effects reported in the first month: Vomiting (around 20% of participants at higher doses) Decreased appetite (this is the intended effect, but it can feel extreme early on) Constipation or diarrhea Fatigue in the first 1 to 2 weeks Mild injection site reactions The glucagon component adds one side effect not seen with semaglutide or tirzepatide
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However, there is still a need to explain why weight loss achieved with semaglutide treatment in people with type 2 Diabetes and obesity or overweight is usually lower than in people without type 2 diabetes
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