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HKC increased the expression of PPAR and its target genes (such as LPL and aP2), PPAR and its target genes (such as LPL, CPT-1, ACO, and CYP4A) in the liver and kidneys of DKD rats
doi: 10.1016/j.fgb.2009.09.003 437 WallG.Lopez-RibotJ
There is also the concern that extended periods on subtherapeutic doses may lead to patient frustration and treatment discontinuation before reaching effective dose levels
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