There are several underlying reasons for the methyl trap: the concentration of Hcy drops, oxidative stress inhibits MS, and the drop in [SAM] releases the inhibition of MTHFR, which drives more folate towards the 5mTHF form
2.6 Mechanistic overview box Mushroom-derived bioactive compounds exert therapeutic effects through several conserved molecular pathways that regulate inflammation, oxidative stress, immune activation, neuroprotection, and cancer progression
This effect is probably caused by reduction in the effects of corticosteroids, which prevent muscle growth, and even probably by a reduction in the activity of myostatin
doi:10.1517/17425250902911455
Accordingly, OCallaghan JM