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10.1104/pp.114.4.1443 49 FrearD
Again, the intervention of Leucine-rich alpha-2 glycoprotein (LRG), a serum biomarker for inflammation in IBD, has shown greater accuracy than CRP in assessing clinical and endoscopic disease activity in UC, suggesting it may be a more reliable marker for inflammation in IBD (199201)
In the mitochondrial pathway, H 2 O 2 increases calcium ion concentrations within the mitochondria [77], regulates Bcl-2 family protein expression and activity, leading to decreased mitochondrial membrane potential, cytochrome c release, and ultimately triggering apoptosis [78]
Under arsenite stress, this METTL3/YTHDF2 interaction is inhibited, which stabilizes CHAC1 mRNA and increases its expression ( In addition to arsenite-induced expression, the CHAC1 gene is transcriptionally activated during cysteine, serine or arginine depletion (Ward et al., 2024)
