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Most cases are mild to moderate, appearing during weeks 26 of therapy as your body adjusts to appetite suppression and weight loss

Lasting results come from combining the medication with lifestyle changes, such as a healthy diet, physical activity, and behavioral changes

Peptides aren't like simple chemical compounds

A key differentiator of Mardrigals resmetirom is that in a pivotal Phase 3 trial, it achieved both primary endpoints of NASH resolution and reduction in fibrosis (MAESTRO-NASH), the two liver histological improvement endpoints the FDA has proposed as reasonably likely to predict clinical benefit

Any insulin dose changes should be gradual with close monitoring