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An RCT of 174 patients with severe alcoholic hepatitis found that the combination of prednisolone + NAC (IV for 5 days, then oral for 2 weeks) significantly reduced 1-month mortality compared to prednisolone alone (8% vs 24%, p=0.006), though the difference was not significant at 6 months (Nguyen-Khac et al., N Engl J Med, 2011) [36]
The results were telling
92 Data from diabetes trials indicate that lixisenatide can improve liver transaminases, especially ALT
Because tirzepatide works in a similar way, experts believe it might have the same benefits, or possibly even stronger effects, due to its dual-action mechanism
It enhances fat oxidation, promoting the breakdown of stored fat for energy, and improves hepatic glucose regulation, supporting better blood sugar control
