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Subsequently, through the action of divalent metal transporter 1 (DMT1), Fe 2+ enters from the endosomes to the labile iron pool (LIP) in the cytoplasm [71]

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3 Macrophage polarization and immunometabolism The functional states of macrophages are not only regulated by microenvironmental inflammatory signals, but are also closely associated with dynamic reprogramming of intracellular metabolic networks, thereby exhibiting a high degree of plasticity