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Pogribna M, Melnyk S, Pogribny I, Chango A, Yi P, James SJ

The study uses structural biophysics-guided computational methods to engineer site-specific missense mutations into the semaglutide peptide backbone, thereby increasing its binding affinity to the extracellular domain (ECD) of GLP-1R

This happens because the action of semaglutide (the active ingredient in both Ozempic and Wegovy) isn't localised to act just on the fat in places we don't want it

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