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According to the FDAs draft guidance, PDURS provides a practical pathway to add a companion software to the label to promote patient outcomes and safety

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Interaction with Medications: May interact adversely with other medications, leading to dangerous side effects

Alterations in the normal function of excitatory amino acid carrier 1 affect cysteine transport and GSH synthesis impairing zinc homeostasis (the thiol group of GSH can function as a principal Zn 2+ chelator for the maintenance of Zn 2+ homeostasis in neurons) and oxidative stress, enhancing susceptibility to ischemia-induced neuronal cell death in the hippocampus (162164)