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However, the immune response of the CNS is complex and involves a myriad of diverse cell populations such as astrocytes, microglia, macrophages, NK cells, and T and B cells (Dringen and Arend, 2025)

These include: Hemodialysis Hemodialysis also often involves blood transfusion and/or administration of erythropoietin or its analogs either of which also require a TUE Treatment for Sickle Cell Disease involves homologous blood transfusions which are prohibited If an athlete requires a Prohibited treatment involving the removal and reintroduction of blood into the circulation for any legitimate medical condition, they should apply for a Therapeutic Use Exemption (TUE) before undergoing the treatment

In addition, sauna use, which induces mild hyperthermia, increases the production of heat shock proteins, which are involved in glutathione maintenance and activity

DDAH is upregulated in IPF, leading to decreased ADMA levels and increased NOS2 activity, thereby enhancing NO production and contributing to fibrotic progression [81]

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