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This means that new or worsening constipation isnt unusual

However, the SUSTAIN clinical trials of Ozempic (semaglutide) showed that in addition to blood sugar control, the drug caused weight loss in participants with Type 2 diabetes and obesity

In people with T2D, retatrutide (0.5 to 12 mg) led to substantial reductions in bodyweight and HbA1c compared to both placebo and dulaglutide 1.5 mg in a phase 2 trial [67]