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The duration of B12 injection effectiveness can vary based on the type of injection administered (hydroxocobalamin, cyanocobalamin, methylcobalamin) and individual metabolism
If pain and restriction in range of motion exist an evaluation is appropriate
Schedule (Once Weekly Injection) Upper limit: 12 mg per week is the highest dose used in the major published clinical trials (Phase 2 obesity, Phase 2 type 2 diabetes, and the Phase 3 TRIUMPH-4 and TRANSCEND-T2D-1 studies)
Intradermal injections are administered very close to the skins surface and require the finest, thinnest needles available for clinical administration
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