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The condition, now known as metabolic dysfunction-associated steatotic liver disease (MASLD), occurs when excess fat accumulates in the liver unrelated to alcohol consumption or viral hepatitis
In addition, energy expenditure is decreased following diet-induced weight loss, with the implication that reduced food intake would need to be maintained in the long-term [12]
Sim R, et al
More serious concerns include a possible increased risk of pancreatitis (inflammation of the pancreas) and, in animal studies, thyroid C-cell tumors
Leptin action in the brain potently suppresses hepatic glucose production while increasing tissue glucose uptake despite persistent, severe insulin deficiency (German et al., 2011)
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