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Overcoming challenges in small-molecule drug bioavailability: a review of key factors and approaches

They included 12 SGLT2i trials with 73,238 participants, of whom 3,065 were on a GLP-1 RA: they found that the benefits of SGLT2i on MACE were consistent regardless of background GLP-1 RA use (HR = 0.81 in patients receiving GLP-1 RA vs HR = 0.90 in those not receiving GLP-1RA) with no significant heterogeneity (p = 0.31)

Fights oxidative stress by neutralizing free radicals Free radicals are natural byproducts of metabolism and pollutants

An agonist is any artificially produced substance that can attach to cell receptors and perform the same function as the naturally occurring substance it is designed to mimic

Lawrence ECN, et al