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13 Pioglitazone is contraindicated in patients with heart failure and thus appropriate care needs to be exercised in its use, but in this context it is of interest that SGLT2 inhibitors may mitigate the fluid retention associated with pioglitazone

Impact of Semaglutide on Body Composition in Adults With Overweight or Obesity: Exploratory Analysis of the STEP 1 Study

Replenish Electrolytes : Use oral rehydration solutions, sports drinks, or coconut water to restore lost electrolytes and maintain balance

That's an 8 variance in active lipotropic load

Choosing nutrient-dense foods: Focus on vegetables, fruits, lean proteins, whole grains, legumes, nuts, and healthy fats 24 , 25