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718 A prospective study evaluating the relationship between plasma ferroptosis biomarkers and prognosis during the hyperacute phase of endovascular thrombectomy (EVT) in patients with acute ischemic stroke found that stroke patients had higher levels of 4-HNE before and after EVT and lower levels of soluble transferrin receptor (sTFR) 24 h after EVT compared with controls

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429 Subsequent studies found that FtMt overexpression reduced ROS and the contents of unstable iron in cytoplasm and mitochondria

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As a reversible PTM, glutathionylation is emerging as a key redox-based signaling mechanism that helps cells respond to environmental stress by regulating specific signaling cascades