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First small molecule permeable and selective for this target

Technically, this is a "lightening" effect

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10.1254/jphs.fp0060070 88 PevecD.NovinscakT.BrcicL.SiposK.JukicI.StaresinicM.et al (2010)

announced that approximately 14 of those 19 restricted peptides are expected to move from Category 2 back to Category 1 status restoring the legal pathway for licensed compounding pharmacies to prepare them under physician prescription