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Gastrointestinal Effects The most commonly reported adverse effects are gastrointestinal in nature, including: Nausea and vomiting (affecting 20-40% of patients initially, varying by agent and dose) [8] Diarrhoea or constipation Abdominal discomfort and bloating Reduced appetite In elderly patients, persistent nausea and vomiting can lead to dehydration and electrolyte imbalances more rapidly than in younger adults
each group comprised both cases and matched control participants
This underscores the urgent need for novel therapies that target the underlying mechanisms of DN
Other carnitine shuttles are active in the endoplasmic reticulum and peroxisomes
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